Research Project

SHRO: excellence in scientific research

SHRO is a nonprofit research organization committed to supporting excellence in scientific research in the fields of regenerative medicine, oncology, and chronic diseases. Our goal is to improve the quality of life through scientific innovation and the discovery of new therapies.

CANCER DEFLECT: Research and Development Project

The use of new molecular analysis technologies on tumors allows us to obtain an almost complete molecular profile of each individual patient's neoplasm in a single analysis. Over time, this has allowed the identification of new molecular targets and new treatment strategies. The reliability and standardization of the data obtained depends on the quality of the initial sample to be analyzed.

The Cancer Deflect project, actively carried out by the SHRO Italia Foundation, has as its primary objective to evaluate the impact of two different mechanical tissue disintegration techniques on the purity and quality of RNA extracted from biopsies of patients suffering from lung tumors. The results obtained and published in the journal Instrumentation Science & Technology (Barbarino, M. et al., 2024) highlight how the Rigeneracons device produced by the Rigenera HBW company, based in Turin, is able to significantly reduce the disaggregation times of the biopsy compared to classical procedures used in clinical practice. Furthermore, samples automatically disrupted with Rigeneracons show superior RNA quality compared to other methods. From a biological point of view, the mechanical disintegration carried out by the device allows the selection of a calibrated population of 80 mm on which future research will be developed. The analysis of cell subpopulations and related markers is a crucial aspect of precision medicine with a direct impact on the diagnosis and prognosis of patients.

CANCER DEFLECT represents an important initiative in the field of oncology research, combining multidisciplinary expertise and advanced technologies to address the complex problem of non-small cell lung cancer. Thanks to the collaboration between academic research and industry, the project aims to develop new therapies and diagnostic tools capable of significantly improving patient prognosis.

SPORT GENOME

Precision medicine in sport: the sports genome project

Precision medicine is not limited to the treatment of tumors, but is also applicable to the diagnosis and management of many other pathologies, including sports medicine. The Sport Genome project focuses on two main aspects:
1. Assess an athlete's relative risk (RR) of sustaining specific injuries, such as anterior cruciate ligament tears or Achilles tendon rupture.
2. Identify individuals at high risk for such orthopedic injuries and provide support in planning individualized training and dietary regimens to prevent or reduce the risk of injury.

The phenomenon of micro-aging

As time passes, the tissues of the human body undergo a natural loss of cells and extracellular material, a process known as “Micro-Aging”. This phenomenon does not only depend on chronological age, but also on hereditary genetic predispositions. After an episode of Micro-Aging, tissues attempt to maintain balance through regeneration and repair processes, influenced by the presence of progenitor cells within the tissues.

Genetic analysis for predisposition to micro-aging

To detect individual predisposition to Micro-Aging it is possible to analyze five specific genes: MCT1, HFE, ACTN3, COL5A1 and VEGF. This is done through a genetic test that identifies specific genetic variants (SNPs) associated with an increased risk of developing certain types of lesions. This test can be performed on a simple saliva sample, providing valuable information for assessing injury risk and planning personalized preventative interventions.

Collaborations with sports organizations

The Sport Genome project is sponsored by various sports entities, including football teams such as Napoli and Fiorentina, Orange Futsal - Asti Soccer and Reale Società Ginnastica Torino. These collaborations allow the project results to be applied to improve the prevention and management of injuries in athletes.